中原地区冠心病患者血脂谱调查与载脂蛋白ApoB/ApoAI比值的意义

Investigation of lipid profile and significance evaluation of ApoB/ApoAI ratio on coronary heart disease patients in central plains region of China

目的:通过分析中原地区冠心病患者血脂谱特征,探讨载脂蛋白B/载脂蛋白AI(ApoB/ApoAI)比值作为冠心病危险因素评估指标的必要性和优势。方法:冠状动脉造影确诊的正常对照组和冠心病患者,进行血脂及载脂蛋白生化分析,统计各血脂谱的相关性,比较各相关系数的差异。结果:①TC、LDL-C、non-HDL-C、ApoB、TC/HDL-C和ApoB/ApoAI各指标在冠心病组显著高于对照组(P<0.05)。②冠心病组HDL-C浓度在各水平分层的比例均明显低于对照组(P=0.002),而TC和LDL-C差异无统计学意义(P>0.05)。③LDL-C与non-HDL-C有最密切的相关性(r=0.959),两者与ApoB/ApoAI的相关性差异无统计学意义(P>0.05),而两者分别与ApoB/ApoAI的相关性与ApoB/ApoAI和ApoB、TC/HDL-C的相关性有显著差异(P<0.05)。结论:中原地区冠心病患者具有低HDL-C的特征,由于各血脂谱统计学相关性的显著差异,ApoB/ApoAI比值可能是反映此类患者心血管病风险的理想标志物和治疗靶点。

Objective：Through analyses of lipid profile on coronary heart disease patients in central plains region of china,we investigated whether the necessity and advantage of ApoB/ApoAI ratio could be a risk factor in coronary heart disease（CHD）.Method：Serum lipid and apolipoprotein of control and CHD patients confirmed by coronary angiography were chemical analyzed.The percentage of different lipid levels divided by Chinese lipid guideline was investigated and compared by t test in two groups.Correlations of different lipid profile were analyzed statistically;and significant difference of correlation coefficient was compared through fisher z transformation.Result：①the value of Total cholesterol（TC）,low density lipoprotein cholesterol（LDL-C）,non-high density liprotein cholesterol（non-HDL-C）,apolipoprotein B（ApoB）,TC/HDL-C ratio and ApoB/ApoAI ratio in coronary heart disease group were significant higher than those in control group（P0.05）,while the concentration of triglyceride（TG） had no significant difference in two groups.The concentration of high density lipoprotein cholesterol（HDL-C） and apolipoprotein AI（ApoAI） were lower significantly than those in control group（P=0.003 and P=0.002,respectively）.②the percentage of HDL-C in different levels in CHD groups had significant difference than those in control groups（P=0.002）,while the percentage of TC and LDL-C in two groups were no significant difference（P0.05）.③LDL-C and non-HDL-C had closest correlation（r=0.959）,and two correlation coefficients of LDL-C with ApoB/ApoAI and non-HDL-C with ApoB/ApoAI were not significant different（P0.05）.But these two indexes had significant difference,respectively,compared with the correlation coefficients of ApoB/ApoAI with ApoB and ApoB/ApoAI with TC/HDL-C（P0.05）.Conclusion：The CHD patients in central plains region of China were characteristic of low HDL-C concentration.For the statistical difference among lipid profile,ApoB/ApoAI ratio would be ideal marker and therapy target in these patients.