PIAS3抑癌效应研究进展

Inhibitory effects of PIAS3 on tumors

肿瘤是一种基因病,涉及到癌基因的激活和/或抑癌基因的失活。在这些基因中,某个或某些基因可能起了关键作用,其通过对下游细胞信号分子或网络的影响,进一步影响细胞的增殖和凋亡过程,造成失控性细胞增殖,最终形成肿瘤。近年来由于对PIAS3生物学功能的进一步认识,其在肿瘤发生发展中的作用也正日益受到了国内外学者的重视。文章将就PIAS3在肿瘤方面的研究进展作一简要介绍。

PIAS3 possesses special functional and structural domains,which have key effects on a variety of important intracellular molecules.PIAS3 inhibits the growth and proliferation of tumors.The roles of PIAS3 in anti-tumor functions are involved in the effects of sumoylation enhancement,resulting in degradation of oncoproteins,inhibition of tumor metabolism,and reducing the activity of transcription factors such as STAT3,Akt,MITF,Oct4 and so on.