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The mystery is solved--CatSper is the principal calcium channel activated by progesterone in human spermatozoa 被引量:2

The mystery is solved--CatSper is the principal calcium channel activated by progesterone in human spermatozoa
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摘要 Aremarkable advance in sperm physiology has recently been published in Nature. Two groups using patch damping techniques on human sperm have solved a mystery about the sperm cell that has puzzled both andrologists and those involved in non-genomic cellular signalling for over 20 years. In these papers, Lishko1 and Strunker2 independently demonstrate that the universal characteristic effect of progesterone on sperm--a rapid influx of calcium--is via a sperm-specific channel CatSper. Aremarkable advance in sperm physiology has recently been published in Nature. Two groups using patch damping techniques on human sperm have solved a mystery about the sperm cell that has puzzled both andrologists and those involved in non-genomic cellular signalling for over 20 years. In these papers, Lishko1 and Strunker2 independently demonstrate that the universal characteristic effect of progesterone on sperm--a rapid influx of calcium--is via a sperm-specific channel CatSper.
出处 《Asian Journal of Andrology》 SCIE CAS CSCD 2011年第3期351-352,共2页 亚洲男性学杂志(英文版)
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  • 1Lishko PV, Botchkina IL, Kirichok Y. Progesterone activates the Principal Ca^2+ channel of human sperm. Nature 2011; 471: 387-91.
  • 2Strunker T, Goodwin N, Brenker C, Kashikar ND, Weyand I et al. The CatSper channel mediates progesterone-induced Ca^2+ influx in human sperm. Nature 2011; 471: 382-86.
  • 3Lishko PV, Botchkina IL, Fedorenko A, Kirichok Y. Acid extrusion from human spermatozoa is mediated by flagellar voltage-gated proton channel. Cell 2010; 140: 327-37.
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  • 8Chung J J, Navarro B, Krapivinsky G, Krapivinsky L, Clapham DE. A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa. Nat Commun 2011; 2: 153.
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