慢性乙型肝炎重叠戊型肝炎感染60例临床分析

Clinical analysis of 60 chronic hepatitis B patients with hepatitis E virus co-infection

目的观察慢性乙型肝炎患者重叠感染戊型肝炎病毒临床特点及戊型肝炎病毒对慢性乙型肝炎患者的影响。方法对60例慢性乙型肝炎病毒重叠戊型肝炎病毒感染组患者与60例单纯慢性乙型肝炎病毒感染组的临床资料进行对照分析。结果 2组的临床生化指标,总胆红素、丙氨酸氨基转移酶、天冬氨酸氨基转移酶、凝血酶原活动度、血白蛋白差异有统计学意义(P<0.01)。重叠感染组HBeAg阴转率、HBV-DNA阳性率低于对照组(P<0.01)。结论慢性乙型肝炎病毒感染者重叠戊型肝炎病毒感染可使病情急性加重,易形成重症化,但戊型肝炎病毒对乙肝病毒复制有一定的抑制作用。

Objective To observe the clinical characteristics of the chronic hepatitis B patients with hepatitis E virus coinfection and the influence of hepatitis E virus on the chronic hepatitis B patients. Methods Clinical analysis was conducted in terms of characteristics of 60 patients with chronic hepatitis B virus overlapped with hepatitis E virus infection and another 60 patients with pure chronic hepatitis B virus infection. Results The difference of clinical biochemistry targets, total bilirubin, alanio amino transferase, aspartic acid amino transferase, zymoplasm original activity and blood albumin of the two groups had statistical significance （ P 〈 0.01 ）. The HBeAg cloudy rate of rotation and HBV-DNA masculine gender rate of the overlap group were lower than the control group （ P 〈 0.01 ）. Conclusion The chronic hepatitis B virus overlapped with hepatitis E virus infection may cause acute aggravation of the condition and thus result in severe liver disease, but the hepatitis E virus has certain inhibitory ability against the hepatitis B virus duplication.