小细胞肺癌患者化疗前后血清CEA.NSE和MMP-2.TIMP-2水平检测的临床意义

Clinical significance of determination of changes of serum CEA.NSE and MMP-2.TIMP-2 levels after chemotherapy in patients with small cell lung cancer

目的探讨肺小细胞肺癌患者化疗前后血清CEA.NSE和MMP-2.TIMP-2水平的变化及临床意义。方法应用放射免疫分析法对33例肺小细胞肺癌患者化疗前后血清CEA.NSE和MMP-2.TIMP-2水平检测,并与35名正常健康人进行比较。结果肺小细胞肺癌患者化疗前血清CEA.NSE和MMP-2.TIMP-2水平均非常显著地高于正常人组(P<0.01),化疗后6个月在未复发的28例中其水平明显下降或接近于正常,而复发5例,其水平又回升至化疗前水平(P<0.01)。结论检测肺小细胞肺癌患者化疗前后血清CEA.NSE和MMP-2.TIMP-2水平的变化可作为肺小细胞肺癌患者诊断和疗效观察的参考。

Objective To explore the changes of serum CEA.NSE and MMP-2.TIMP-2 levels after chemotherapy in patients with small cell lung cancer（SCLC）.Methods Serum CEA.NSE and MMP-2.TIMP-2（with RIA） levels were determined in 33 patients with SCLC both before and after chemotherapy as well as in 35 controls.Results Before chemotherapy,serum CEA.NSE and MMP-2.TIMP-2 levels in the patients were significantly higher than those in the controls（P0.01）.Six months after chemotherapy the levels in 28 cases without recurrence remained dropping markedly and approached those in controls.However in 5 patients with recurrence the levels increased again and approached those before chemotherapy.Conclusion Detecting levels of serum CEA.NSE and MMP-2.TIMP-2 might be a useful reference for diagnose and therapeutic effects in patients with SCLC.