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促凋亡基因puma的研究进展 被引量：1

Research Progress of Proapoptic Gene puma
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摘要 p53上调凋亡调控因子(puma)可通过p53依赖途径和p53非依赖途径诱导多种肿瘤细胞的凋亡,可能在肿瘤及自身免疫性疾病的发生、发展和治疗中发挥重要的作用,并有望成为人类肿瘤和凋亡相关疾病治疗的新靶点。现就其结构和功能、促凋亡作用、化学药物对多种细胞株中puma表达水平的影响、其他转录途径调节以及转录后调节puma予以综述。 p53 up-regulated modulator of apoptosis（puma）acts as an essential mediator of apoptosis via p53-dependent and p53-independent mechanisms,which may play a prominent role in the formation,development,treatment of tumors and autoimmune diseases.It can be potentially used as a new target for anticancer and apoptosis-associated diseases therapy.Here is to review its structural characteristics,function,pro-apoptotic role,chemical drugs influence on the expression of puma in several cell lines,other transcription pathways regulation and post-transcription regulation of puma.
作者 宋宇 段勇 王玉明
机构地区 昆明医学院第一附属医院检验科
出处 《医学综述》 2011年第12期1791-1794,共4页 Medical Recapitulate
关键词 p53上调凋亡调控因子 凋亡 细胞株 p53 up-regulated modulator of apoptosis Apoptosis Cell Lines
分类号 R730.54 [医药卫生—肿瘤]
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参考文献32

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二级参考文献39

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共引文献11

同被引文献9

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医学综述
2011年 第12期

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