内皮特异性分子1与肿瘤的研究进展

Advancement of the Research on the Relationship between ESM-1 and Tumor

内皮特异性分子1(ESM-1)最初是对人脐静脉内皮细胞的cDNA文库克隆时意外发现的长度为2kb的cDNA序列,该序列可编码一种可溶性蛋白多糖,又称为Endocan。目前ESM-1的生物学功能尚在研究中,初步的研究结果表明,它与动脉硬化、炎症、肿瘤的发展、血管、淋巴管的生成,以及多种生物分子调控机制都有着重要的关系。但对于ESM-1在肿瘤中的研究,如与肿瘤相关性的炎症、血管增生等的具体作用机制等仍有争议。同时关于它在肿瘤淋巴管增生方面的研究,也处于起步阶段。现对近几年来关于ESM-1与肿瘤的发生、发展之间的研究予以综述。

Endothelial-specfic molecule-1（ESM-1）,also called Endocan,is a soluble proteoglycan encoded by a 2kb cDNA which was first found by Lassalle when they were cloning the cDNA of human umbilical vein endothelial cell.The biological function of ESM-1 is still under study and some studies show it plays an important role in arteriosclerosis,inflammation,tumor development,blood and lymph vessel formation and various molecular regulating mechanisms.However,the study of its role in the lymph vessel proliferation of tumor has just started.Here is to review the recent studies on the relations between ESM-1 and the formation/progression of tumors.