摘要
目的观察胚胎神经干细胞移植治疗脑出血后遗症的临床疗效。方法 5例患者,平均55岁,其中基底节出血术后2例,内囊出血2例,丘脑出血1例。选择胚胎神经干细胞治疗,在手术室腰椎穿刺植入3 mL内含108级的干细胞混悬液,同时注入0.9%氯化钠注射液1 mL;地塞米松注射液5 mg,每周1次,共4次。采用统一神经功能缺损评定评分。结果胚胎神经干细胞移植后1~36 h 2例出现发热,体温为37.6~38.0°C,3例头痛、头晕,2例出现腰痛和腿痛。结论胚胎神经干细胞移植对改善脑出血后遗症有效,显著提高生存质量。
Objective To evaluate the clinical effects of embryonic stem cell（ESC）treating cerebral hemorrhage sequelae.Methods 5 patients with an average age of 55,including 2 with post-surgery basal ganglia hemorrhage,2 with internal capsule hemorrhage,and 1 with thalamus hemorrhage were studied.The operation was conducted via lumbar puncture in the operation room.Stem cell suspension（3 mL）with the quantity of 108,0.9% sodium chloride injection（1 mL）and desamethasone injection（5 mg）are injected into the patients during the operation.The operation is done on a weekly basis,and the patients receive 4 injections altogether.The result is scored by unified standard on dysneuria extent.Results 2 patients developed a low fever（around 37.6~38.0℃）in 1 to 36 hours after ESC transplantation.3 patients felt headache and dizzy.2 patients developed lumbago and skelalgia.Conclusion ESC transplantation is effective in treating cerebral hemorrhage sequelae.The patients′ life quality improves significantly after ESC treatment.
出处
《医学综述》
2011年第12期1908-1909,共2页
Medical Recapitulate
关键词
胚胎神经干细胞
移植
脑出血后遗症
Embryonic stem cell
Transplantation
Cerebral hemorrhage sequelae
