白细胞介素8在重型颅脑损伤患者脑脊液中的变化及意义
摘要
白细胞介素8(interleukin-8,IL-8)由69-79个氨基酸组成,属于有化学增活素作用的半胱氨酸家族成员,有增强中性粒细胞趋化性和激发其活性的作用。近来的实验表明IL-8参与了中枢神经系统的炎症反应。在动物模型和临床上,创伤性脑损伤(traumatic braininjury,TBI)引发以前炎症性和抗炎症性细胞因子的产生、血管黏附分子的上调及损伤脑组织内温度依赖的中性粒细胞积聚为特征的急性炎症反应。
出处
《临床荟萃》
CAS
2011年第14期1242-1244,共3页
Clinical Focus
参考文献10
-
1Baggiolini M, Moser B, Clark-Lewis I. Interleukin-8 and related chemotactic cytokines: the Giles Filley Lecture [J]. Chest, 1994,105(3 Suppl) :95S-98S.
-
2Proost P,Wuyts A, van Damme J. The role of chemokines in inflammation [J]. Int J Clin Lab Res,1996,26(4):211-223.
-
3Kossmann T, Stahel PF, Lenzlinge PM, et al. Interleukin-8 released into the cerebrospinal fluid after brain injury is associated with blood-brain barrier dysfunction and nerve growth factor production[J]. J Cereb Blood Flow Metab, 1997, 17(3) :280-289.
-
4Kettritz R, Gaido ML, Hailer H, et al. Interleukin-8 delays spontaneous and tumor necrosis factor-alpha-mediated apoptosis of human neutrophils[J]. Kidney Int, 1998,53 (1) : 84-91.
-
5Hoch RC, Schraufstatter IU, Cochrane CG, et al. In vivo, in vitro, and molecular aspects of interleukin-8 and the interleukin-8 receptors[J]. J Lab Clin Med, 1996 , 128(2) : 134- 145.
-
6Rampart M, van Damme J, Zonnekeyn L, et al. Granulocyte chemotatic protein/interleukin-8 induces plasma leakage and neutrophil accumulation in rabbit skin[J]. Am J Pathol, 1989, 135(1) :21-25.
-
7Bell MD,Tabb DD, Perry VH, et al. Overriding the brain' s intrinsic resistance to leukocyte recruitment with intraparenchymal injections of recombinant ehemokines[J]. Neuroscience, 1996,74(1) : 283-292.
-
8Matsumoto T, Ikeda K, Mukaida N, et al. Prevention of cerebral edema and infarct in cerebral reperfusion injury by anantibody to interleukin-8 [J]. Lab Invest, 1997, 77 ( 2 ) : 119- 125.
-
9Araujo DM, Cotman CW. Trophic effect of interleukin-4,-7, and 8 on hippocampal neuronal cultures: potential involvement of glial-derived factors[J]. Brain Res, 1993, 600 (1) :49-55.
-
10Norrby K. Interleukin-8,and de novo mammalian angiogenesis [J]. Cell Prolif, 1996,29(6), 315-323.
-
1尹昌林,徐世伟,文亮.重型颅脑损伤后脑脊液IL-8的变化及意义[J].中华创伤杂志,2001,17(10):621-622. 被引量:8
-
2秦天森,廖达光.21例脑脊液瘘临床分析[J].湖南医科大学学报,1992,17(4):385-386.
-
3唐毓金.腰椎手术发生硬脊膜损伤19例[J].右江民族医学院学报,2002,24(3):371-371. 被引量:1
-
4李云辉,梁瑞奇,罗晓阳,杜军,张桂萍,成晓玲,张彦霞,王育敏,朱蓉.血管加压素在急性颅脑损伤中的意义[J].中国冶金工业医学杂志,1994,11(2):68-70.
-
5李牧,刘敬业,薛庆澄.脑外伤后脑脊液乳酸、丙酮酸变化的临床意义[J].中华神经外科杂志,1989,5(3):205-209. 被引量:6
-
6尹邦良,詹樾.深低温体外循环病人脑脊髓液肌酸磷酸激酶及其同功酶的研究[J].湖南医科大学学报,1993,18(4):424-426.
-
7刘磊,宁波,马宇洁,李一粟,刘涛.脑脊液乳酸在颅脑损伤亚低温治疗效果评价中的作用[J].中国误诊学杂志,2011,11(6):1356-1356. 被引量:2
-
8刘子生,张叔辰,朱诚,张光霁,王成海,林葆城,路长林.血浆和脑脊液中强啡肽—A含量变化与脑外伤的关系[J].中国冶金工业医学杂志,1994,11(2):71-73.
-
9方永军,杨国材,张毅,范小璇,周锋,周雄波,侯文.去骨瓣减压术后切口脑脊液漏的防治[J].陕西医学杂志,2013,42(10):1342-1343. 被引量:2
-
10王茂德,刘守勋,谢万福,王拓,刘昊,鲍刚.颅脑损伤患者血浆、脑脊液NO含量变化的临床研究[J].陕西医学杂志,2001,30(8):453-456. 被引量:1