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微小RNA在免疫系统和类风湿关节炎中的作用 被引量：3

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摘要 微小RNA（microRNA，miRNA）是一类长约21～25个核苷酸的非编码单链小RNA，其在不同类型免疫细胞的分化发育、固有免疫、适应性免疫及炎症因子的信号转导过程中起着重要的调节作用，参与自身免疫性疾病及炎症性疾病的发病过程，现就miRNA在免疫系统中的作用和参与类风湿关节炎（rheumatoid arthritis，RA）发病过程作一综述。1miRNA的生物合成、作用机制miRNA主要由基因间隔区的核酸序列编码，
作者 高登文 钱龙
机构地区 安徽医科大学附属省立医院风湿免疫科
出处 《中华风湿病学杂志》 CAS CSCD 北大核心 2011年第6期416-420,共5页 Chinese Journal of Rheumatology
关键词 类风湿关节炎 微小RNA 免疫系统 自身免疫性疾病 miRNA 发病过程 适应性免疫 炎症性疾病
分类号 R392 [医药卫生—免疫学]
  • 相关文献

参考文献25

  • 1Zhao Y, Srivastava D. A developmental view of microRNA function. Trends Biochem Sci, 2007, 32: 189-197.
  • 2Xiao CC, Rajewsky K. MicroRNA control in the immune system: basic principles. Cell, 2009, 136: 26-36.
  • 3Lu LF, Boldin MP, Chaudhry A, et al. Function of miR-146a in controlling Treg cell-mediated regulation of Thl responses. Cell, 2010, 142: 914-929.
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二级参考文献8

  • 1Nakasa T,Miyaki S,Okubo A,et al.Expression of microRNA-146 in rheumatoid arthritis synovial tissue.Arthritis Rheum,2008.58:1284-1292.
  • 2Stanczyk J,Leslie-Pedrieli DM,Brentano F,et al.Alteredexpression of microRNA in synovial fibroblasts and synovialtissue in rheumatoid arthritis.Arthritis Rheum,2008.58:1001-1009.
  • 3Amett Fc,Edworthy SM,Bloch DA,et al.The AmericanRheumatism Association 1987 revised eriteria for theclassification of rheumatoid arthritis.Arthritis Rheum,1988.31:3 15-324.
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  • 6Tang Y,Luo X,Cui H,et al.MieroRNA-146a contributes toabnormal activation of the type I interferon pathway in humanlupus by targeting the key signal ing proteins.Aahrifis Rheum,2009,60:1065一1075.
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共引文献10

同被引文献5

引证文献3

二级引证文献9

中华风湿病学杂志
2011年 第6期

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