掺杂钠硅磷灰石水泥多孔支架用于骨缺损再生修复

Study on Adulterate Sodium Silica Apatite Cement Porous Scaffolds for Bone Defect Repair

采用磷酸四钙和磷酸氢钙为磷灰石水泥(AC)粉末,5wt%硅酸钠水溶液为固化液,氯化钠为致孔剂,制备了掺杂钠元素的硅磷灰石水泥(s-AC)多孔支架用于骨缺损再生修复.结果显示:s-AC多孔支架的成分为含钠硅元素的磷灰石,支架大孔之间互相贯通,孔径在200～600μm,孔隙率在58%～75%,抗压强度在1.6～3.8MPa的范围内.与AC相比,掺杂一定量的钠硅元素提高了s-AC支架在Tris-HCl溶液中的降解性.将s-AC多孔支架植入兔股骨缺损处,组织学分析结果显示:新生骨在支架材料的表面直接形成,并长入其中,相互贯通的多孔支架促进了新骨长入其内部.结果表明:s-AC支架具有优良的生物相容性、降解性和成骨性,将是一种优良的骨修复生物材料.

Adulterate sodium silicon apatite cement（s-AC） porous scaffolds for bone repair were prepared by us-ing the mixed powders of tetracalcium phosphate and dicalcium phosphate anhydrous,5wt% sodium silicate water-solution as cement liquid,and NaCl particles as progens.The result shows that the composition of the s-AC scaf-folds is sodium silicon apatite.The macroporous sizes of the scaffolds were in the range from 200 μm to 600 μm,the porosity of the scaffolds is from 58% to 75%,and the macropores were interconnected with each other.The compressive strength of the s-AC scaffolds is from 1.6MPa to 3.8MPa,and the degradability of sodium silicon doped s-AC scaffolds improves significantly as compared with AC in Tris-HCl solution.When the s-AC scaffolds are implanted in femur bone defect of rabbits,the histological analysis results show that the new bone tissue is formed on the surfaces and ingrew into the interior of the scaffolds,the well interconnected macropores promoted the bone tissue ingrowth into the scaffolds.In conclusion,the s-AC scaffolds exhibit good biocompatibility,de-gradability and osteogenesis in vivo,which will be a good biomaterial for bone repair.