International Normalized Ratio:青年脑梗死危险因素

International Normalized Ratio:Risk Factor for Cerebral Infarction at Young Age

目的评估入院时国际标准化比值水平对青年脑梗死患者出院时短期预后的影响。方法分析585例患脑梗死的青年患者,这些患者从来未服用华法令。所有患者都在发病48h后入院,脑影像学检查(CT或者MRI)在入院后24～48h后进行。结果通过logistic回归模型,笔者发现较高的INR和纤维蛋白原水平预示着患者在出院时有较差的预后。结论应用该回归分析模型,笔者确定INR是青年脑梗死患者临床预后的独立危险因素,因此入院时INR的水平不仅仅是凝血功能检测的指标,而且将为青年脑梗死患者提供一个实用的临床预后信息。

Objective To evaluate association admission INR values with discharge outcome in young cerebral infaretion patients. Methods We analyzed the relation between INR levels and prognosis as determined by the modified Rankin Scale at discharge in .585 young patients who had never taken warfarin. By logistic regression modeling, we determined the influence of INR on stroke severity. Results There were much higher INR and fibrinogen levels in patients with poor prognosis at discharge. A logistic regression confirmed the admission INR predict independently poor discharge outcome. Conclusion It also seems that admission INR may provide addilional general prognostic information not only anticoagulated biomarker.