TBI大鼠海马糖皮质激素受体表达变化对认知功能的影响

Cognitive function changes in response to expression of glucocorticoid receptor from rat hippocampus after traumatic brain injury

目的研究创伤性脑损伤（traumatic brain injury，TBI）后大鼠海马区糖皮质激素受体（glucocorticoid receptor，GR）表达的变化对认知功能的影响。方法建立大鼠脑损伤模型，应用免疫组化、Westernblot和Morris水迷宫检测伤后大鼠海马区GR表达与学习记忆功能的关系。结果伤后4—10d大鼠海马区GR持续低表达；Morris水迷宫检测伤后大鼠出现认知功能障碍。结论TBI大鼠海马区GR表达变化与认知功能的障碍改变具有相关性。

Objective To .explore the effect of glucocorticoid receptor （GR） expression in rat hil？pocampus on cognitive function after traumatic brain injury （TBI）. Methods The TBI model was established in rats. Then, immunohistochemistry and Western blot were used to detect the GR expression and evaluate its relation with cognitive dysfunction by Morris water maze. Results Expression of hippocampal GR was down-regulated 4-10 days after TBI. Morris water maze test showed significant impairment of the cognitive function in rats. Conclusion There is correlation between expression change of hippocampal GR and cognitive dysfunction.