对甲基乙酰苯胺的合成

Synthesis of p-acetotoluidide

以对甲基苯胺与冰醋酸为原料,通过酰化反应合成对甲基乙酰苯胺,考察了反应物摩尔比、反应时间及反应温度对反应的影响。结果表明,合成对甲基乙酰苯胺的最佳实验条件是:冰醋酸与对甲基苯胺物质的量之比为2.5∶1,反应时间为60 min,反应温度为105℃,收率84%。

p-Acetotoluidide was synthesized from p-toluidine and acetic acid through acylation reaction.The effect of molar ratio,reaction temperature and reaction time on reaction were discussed.Results showed that the best experiment conditions were as follows： molar ratio of acetic acid to p-toluidine was 2.5∶1,reaction time was 60 min,reaction temperature was 105 ℃.The yield was 84%.