呼吸道感染婴幼儿肠道轮状病毒携带导致院内发生轮状病毒性腹泻的研究

Theimpact of intestinal rotavirus respiratory infection for infants suffering rotavirus diarrhea in hospitals

目的探讨呼吸道感染婴幼儿肠道轮状病毒携带在医院内发生轮状病毒性腹泻中的作用。方法应用队列研究方法，选取在入院前大便正常的因呼吸道感染住院的婴幼儿进行研究，在入院当天收集粪便进行轮状病毒抗原的检测，阳性者列为暴露组，阴性者列为对照组。然后追踪其发生轮状病毒性腹泻的发病情况。结果呼吸道感染的婴幼儿肠道轮状病毒的携带率为6．8％。暴露组轮状病毒性腹泻的发生率为73．9％，对照组轮状病毒性腹泻的发生率为6．0％；两组经统计学检验，差异具有统计学意义（x2=103．789，P〈0．01）。暴露组发生轮状病毒性腹泻的相对危险度为12．3。结论呼吸道感染的婴幼儿肠道携带轮状病毒是医院内发生轮状病毒性腹泻的一个重要的危险因素。

Objective The thesis is aimed to detect the impact of respiratory intestinal rotavirus on infants infected with rotavirus diarrhea in hospitals. Methods A cohort method is applied to study the in-hospital infants due to the respiratory tract infection who are normal with their bowels movement. Their feces were collected and detected for rotavirus antigen the day when they were hospitalized. Positive ones were selected as the exposed group while negative ones as control group. The incidences of rotavirus diarrhea among the clients were traced. Results The carrying rat of for the respiratory infected infants with intestinal rotavirus was 6.8%. The incidence rate of rotavirus diarrhea among exposed group was 73.9%, while control group was 6.0%. Statistical test showed that there were statistical differences between these two rates （P 〈 0.01, x2= 103.789）. The relative risk in exposed group suffering rotavirus diarrhea was 12.3. Conclusion Among those respiratory infected infants, the intestinal rotavirus is an critical risky factor leading to rotavirus diarrhea in hospitals.