血清CEA、CA19-9联合检测与结直肠癌关系的研究

The relation of serum CEA and CA19-9 in the diagnosis of colorectal cancer

目的探讨肿瘤标志物CEA、CA19-9联合检测在结直肠癌诊断中的应用价值。方法用电化学发光法对54例结直肠癌、50例良性肠道疾病患者血清中CEA、CA19-9的水平进行检测。结果结直肠癌组患者血清中CEA、CA19-9的水平明显高于良性疾病组(P<0.01)。结直肠癌组CEA、CA19-9联合检测阳性率(66.7%)高于单项检测阳性率(42.6%、38.9%,P<0.05),而CEA、CA19-9单项检测的阳性率则无明显差异(P>0.05)。CEA、CA19-9单项检测的敏感性分别为42.6%、38.9%,特异性分别为90%、92%,均无统计学意义(P>0.05);CEA、CA19-9联合检测的敏感性(66.7%)较单项检测显著提高(P<0.01),而特异性有所降低(86.0%),但无统计学意义。结论肿瘤标志物联合检测用于结直肠癌诊断的价值优于单项检测。

Objective To investigate the applicative significance of colorectal cancer. Methods The serum levels of CEA and CA19 - 9 were CEA and CA19-9 in the diagnosis of determined by CLIA in 54 patients with colorectal cancer and 50 patients with benign digestive diseases. Results The serum levels of CEA and CA19-9 were significantly higher in patients with colorectal cancer than in patients with benign digestive diseases （P 〈0.01）. The positive rate of joint diction of CEA and CA1909 was higher than that of the single item examination, which was 42.6% and 38.9% （P〈0.05）. The positive rate of single item examination of CEA and CA19-9 had no statistical difference （P〉0.05）. The specificity rates of CEA and CA19-9 were 90% and 920, with not statistical difference （P〉0.05）. Conclusion The joint detection of CEA and CA19-9 has better diagnostic value than the single item examination