摘要
以2,4-二氟硝基苯、溴代乙酸乙酯和丙炔溴等为原料,经取代、醚化、还原关环、硝化、N-烷基化、再还原后得中间体7-氟-6-胺基-2H-1,4-苯并嗯嗪-3(4H)-酮,在醋酸溶剂中与3,4,5,6-四氢苯酐反应得到目的产物丙炔氟草胺。经IR和1H—NMR测定,产品结构与丙炔氟草胺一致。总收率28%。
6-amino-7-fluoro-4-(2-propynyl)-2H-1,4-benzoxazin-3(4H)-one, an intermediate of flumioxazin, was synthesized using 2,4-difluoronitrobenzene as primary material, following by hydroxyl substitution, etherification with ethyl bromoacetate, reduction with Fe powder and N-alkylation with propargyl bromide. Then flumioxazin was prepared with 6-amino-7-fluoro-4-(2-propynyl)- 2H-1,4-benzoxazin-3(4H)-one and 3,4,5,6-tetrahydrophthalic anhydride in acetic acid solution by reflux. Their structures were confirmed by IR, NMR. The total yield was above 28%.
出处
《世界农药》
CAS
2011年第2期27-29,共3页
World Pesticide