L-氨基酸席夫碱的无溶剂法合成及其结构表征

Solvent-Free Synthesis and Characterization of L-Amino Acids Schiff Bases

报道了一种新颖的L-氨基酸席夫碱的制备方法.L-丙氨酸(L-ala),L-丝氨酸(L-ser),L-缬氨酸(L-val),L-亮氨酸(L-leu),L-异亮氨酸(L-Ile),L-苯甘氨酸(L-phg),L-苯丙氨酸(L-phe)七种氨基酸与水杨醛或2-羟基-1-萘醛在氢氧化钾存在下,室温研磨得到相应的氨基酸席夫碱.所得产品经核磁共振氢谱、碳谱、红外光谱、质谱、元素分析等检测手段进行结构表征.实验结果表明,该反应室温只需10 min即可进行完全,产品纯度好,收率大于90%.

A new solvent-free method was described for the synthesis of L-amino acids Schiff bases by the reactions of L-alanine（L-ala）,L-serine（L-ser）,L-valine（L-val）,L-leucine（L-leu）,L-isoleucine（L-Ile）,L-phenylglycine（L-phg）,L-phenylalanine（L-phe） with salicylaldehyde or 2-hydroxy-1-naphthaldehyde,re-spectively,in the present of KOH at room temperature.The structures of these compounds were confirmed by 1H NMR,13C NMR,IR,MS techniques and elemental analysis.The results showed that the reaction time is only 10 min and the purity of the amino acids Schiff bases is pretty good and the yields are up to 90%.