4-苯氨基喹唑啉类衍生物的合成、表征及晶体结构

Synthesis,Characterization and X-ray Structure of 4-Phenylamino Quinazoline Derivatives

以香草醛为原料,经过7个步骤合成得到了12个新的4-苯氨基喹唑啉类化合物8a～8l,产物的结构经1H NMR,13C NMR,IR,MS和元素分析确认,并用X射线衍射法测定化合物8b的晶体结构.化合物8b属三斜晶系,P-1空间群,晶胞参数:a=0.8868(5)nm,b=1.0239(6)nm,c=1.4515(9)nm,α=71.02(2)°,β=82.42(2)°,γ=71.78(2)°,V=1.1831 nm3,Z=2,Dc=1.430 Mg/m3,μ(Mo Kα)=1.773 mm-1,λ=0.071073 nm,F(000)=522.

Twelve new compounds,4-phenylamino quinazoline compounds 8a？？8l,were synthesized from vanillin by seven steps reaction.Their structures were characterized by 1H NMR,13C NMR,IR,MS tech-niques and elemental analysis.Compound 8b was investigated with X-ray crystallography.The crystal of 8b belongs to Triclinic,space group P-1 with cell parameters a=0.8868（5）nm,b=1.0239（6）nm,c=1.4515（9）nm,α=71.02（2）°,β=82.42（2）°,γ=71.78（2）°,V=1.1831 nm3,Z=2,Dc=1.430 Mg/m3,μ（Mo Kα）=1.773 mm-1,λ=0.071073 nm,F（000）=522.