CK-MB在新生儿窒息脑损伤诊断中的价值研究

Study on value of CK-MB% in diagnosing Neonatal Asphyxia with brain damage

目的:研究CK-MB在反映新生儿窒息所致的脑损伤中的临床意义及诊断价值。方法:收集49例实验组及20例对照组,其中将实验组分成合并脑损伤(27例)和不合并脑损伤(22例)两对比组,分别采用自动生化分析仪法与琼脂糖凝胶电泳法检测其总CK活性、同工酶活性和CK-MB%。结果:(1)对照组两方法测定结果比较,自动生化分析仪法测定的CK-MB%高于琼脂糖凝胶电泳法(简称电泳法)检测的结果(P<0.01)。实验组中自动生化分析仪测定的CK-MB%高于电泳法检测的结果(P<0.01)。对照组和实验组比较,CK-MB%测定结果无差别(P>0.05)。(2)实验组中合并脑损伤组中CK-MB%和不合并脑损伤组比较,测定结果无差别(P>0.05)。结论:自动生化分析仪法测定的CK-MB%明显高于电泳法检测的CK-MB%。上述两种方法检测的CK-MB%在实验组和对照组间以及在新生儿窒息中是否合并脑损伤并无显著性差异,不宜作为诊断新生儿窒息所致的脑损伤的生化指标。

Objective：To study the value of CK-MB in diagnosing neonatal asphyxia with brain damage.Methods： 69 patients（22 neonatal asphyxia,27 neonatal asphyxia with brain damage,20 normal） were evaluated with total CK,CK-MB,calculate CK-MB ratio using automatic biochemical analyser and agarose sugar electrophoresis method.Results：（1）The results of CK-MB% measured by automatic biochemical analyser were higher than the agarose sugar electrophoresis in the control group and the test group（P0.01）.Compared between two groups,results were indifferent（P0.05）.（2） Compared the brain damage group with neonatal asphyxia group,results were indifferent（P0.05）.Conclusion： The results of CK-MB% measured by automatic biochemical analyser were significantly higher than the agarose sugar electrophoresis.The results of CK-MB% may not be regarded as a biochemical indicator in diagnosing neonatal asphyxia with brain damage.