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对比剂对大鼠肾近球小管钠钾ATP酶活性的影响 被引量：3

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摘要 目的探讨对比剂对大鼠单根肾近球小管钠钾ATP酶(Na+,K+-ATPase)活性的影响,比较不同渗透压对比剂急性肾损伤的差异,探讨对比剂肾病的发病机制。方法选成年健康SD大鼠,经尾静脉注射等量高渗、低渗对比剂和生理盐水,72 h后取材;显微镜下微分离法获取大鼠单根肾近球小管,电镜鉴定,液闪法测定Na+,K+-ATPase活性。结果与生理盐水对照组相比,高渗、低渗对比剂组大鼠单根肾近球小管的Na+,K+-ATPase活性明显降低(均P<0.01),高渗组较低渗组明显,但两组间差异无统计学意义。结论对比剂显著抑制大鼠肾近球小管Na+,K+-ATPase的活性,但对于正常大鼠,高渗与低渗间无明显差异。
作者 陈曦 李军 姜小飞 石理
机构地区 广东省珠海市人民医院心内科
出处 《广东医学》 CAS CSCD 北大核心 2011年第11期1405-1407,共3页 Guangdong Medical Journal
关键词 对比剂 对比剂肾病 钠钾ATP酶 大鼠
分类号 R544.105 [医药卫生—心血管疾病]
  • 相关文献

参考文献13

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共引文献25

同被引文献21

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引证文献3

二级引证文献1

广东医学
2011年 第11期

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