中药方剂对试验性鸡葡萄球菌性关节炎保护的组织病理学研究

Histopathological study on protection of the Chinese herbal medicine prescription against experimental Staphylococcus aureus arthritis in chickens

采用右侧关节腔直接接种金黄色葡萄球菌的方法人工复制鸡葡萄球菌性关节炎的病理模型,通过在饲料中添加一定比例的中药方剂,并在接种金黄色葡萄球菌后第7、14、21、35天,各组随机取4只鸡进行剖杀,取心、肝、肺、肾等脏器进行组织病理学观察,检测本教研室所组方剂对鸡葡萄球菌性关节炎的防治效果。结果表明,试验组鸡的脏器变化趋势与感染对照组鸡相似,均为试验初期急性病变,此后病变逐渐减轻,但试验组鸡的脏器在初期明显较感染对照组的病变轻,且此后病变减轻与恢复出现的时间早,速度快。表明,本试验所用中药方剂具有保护内脏器官,促进组织恢复的功能,可以预防和治疗鸡葡萄球菌性关节炎。

Healthy chickens were infected with Staphylococcus aureus into right hock to develop experimental S.aureus arthritis,and histopathological method was used to observe the effect of Chinese herbal medicine prescription,which was supplemented into feed by ratio,on the heart,liver,lung,kidney and other organs of the infected chickens.In result,the pathological changes of the control group and infected group were similar to the experimental group,the early of infection was acute disease and recovered certain degree gradually.But the pathological change of the infected group was slight and recovered quickly.The results showed that Chinese herbal medicine prescription could prevent and cure staphylococcus arthritis in chickens.