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Primary stromal cells isolated from human various histological/pathological prostate have different phenotypes and tumor promotion role 被引量:4

Primary stromal cells isolated from human various histological/pathological prostate have different phenotypes and tumor promotion role
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摘要 Background Prostate stromal cells are known to regulate epithelial growth as well as support and maintain epithelial function. However, how stromal cells regulate epithelial cells and what differences among various histological/pathological prostate stromal cells in prostate cancer progression still remain unclear. This study aimed to investigate the different phenotypes of human various histological^pathological prostate stromal cells, and their role in tumor promotion. Methods The different phenotypes of the human normal prostatic peripheral zonal primary stromal cells (NPPF), transitional zonal primary stromal cells (NPTF), Background Prostate stromal cells are known to regulate epithelial growth as well as support and maintain epithelial function. However, how stromal cells regulate epithelial cells and what differences among various histological/pathological prostate stromal cells in prostate cancer progression still remain unclear. This study aimed to investigate the different phenotypes of human various histological^pathological prostate stromal cells, and their role in tumor promotion. Methods The different phenotypes of the human normal prostatic peripheral zonal primary stromal cells (NPPF), transitional zonal primary stromal cells (NPTF),
出处 《Chinese Medical Journal》 SCIE CAS CSCD 2011年第11期1700-1707,共8页 中华医学杂志(英文版)
基金 This study was supported by the grants from the National Natural Science Foundation of China (No. 81072096) and the Science and Technology Commission of Shanghai Municipality (No. 074119518).
关键词 cluster analysis peripheral zone prostate cancer stromal cells cluster analysis peripheral zone prostate cancer stromal cells
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