克山病患者T细胞亚群分析及病区粮因素对大鼠T细胞功能的影响

ANALYSIS OF THE SUBSETS OF T CELL IN PATIENTS WITH KESHAN DISEASE AND THE INFLUENCE OF THE DISEASE AREA FACTORS ON T CELL FUNCTION IN RATS

作者用OKT系统单克隆抗体检测克山病患者T淋巴细胞亚群,发现患者T淋巴细胞亚群数量存在明显异常;用小鼠胸腺细胞生长法检测病区粮喂养大鼠的IL-2活性,发现实验组明显低于非病区粮对照组,但病区粮加硒组大鼠IL-2活性有显著提高。提示克山病的发生可能与自身免疫反应有关,病区粮因素能够降低大鼠的T细胞功能,微量元素硒具有增强机体细胞免疫功能的作用。

In this paper lymphocyte monoclonal antibodies were used to determine subpopulation of T cell in patients with Keshan disease and abnormal subpopulation was found. Activity of IL-2 in rats which fed with diet from disease area was much lower than that in controls. The activity of IL 2 enhanced when selenium was administrated to the diet. It is possible that Keshan disease may be an autoimmune disease and the disease factors could damage T cell function. Selenium (Se) could enhance cellularimmunity.