摘要
用薄层色谱法定性分析萘普生合成中的10 种中间体, 使用乙酸乙酯∶环己烷= 1∶4( V/ V) 作展开剂, 在萘普生合成工艺中可用于丙酰基化、溴代和缩酮化等反应进行程度的监测,分析效果好。
Ten intermediates in the synthesis of naproxen were analyzed qualitatively by TLC with the mixture of ethyl acetate and cyclohexane as a developping agent. The method has been used to determination of the reaction degree of propionylization, bromination and ketalization in the synthesis of naproxen with satisfied results.