高血压患者肠系膜小动脉血管的病理变化

Pathological change of mesenteric arteriole in patients with essential hypertension

目的:观察高血压患者肠系膜小动脉血管的病理变化。方法:分别从非高血压(n=16)、高血压(n=16)以及高血压合并左心室肥厚患者(n=14)外科取肠系膜三级小动脉,经HE染色后光学显微镜下观察血管形态,分析血管壁厚度(WT)、血管壁厚度与内径比值(WT/ID)、血管壁与血管腔横截面积比值(WCSA/LCSA)以及血管外径(OD)。结果:血管外径(OD)在三组之间无统计学差异。高血压病组和左室肥厚组的WT、WT/ID和WCSA/LCSA显著高于对照组;与高血压病组比较,左室肥厚组的WT、WT/ID和WC-SA/LCSA值明显增加,而ID则明显减小(P<0.05)。结论:原发性高血压患者肠系膜小动脉发生向心性重构,合并有左室肥厚者重构更明显。

Objective ：To observe the pathological characteristics of ruesenteric arteries in patients with essential hypertension. Methods ： Mcscnteric arteries were obtained from patients with hypertension （ n = 16）, hypertension associated with left ventricular hypertrophy （ n = 14 ） and nonhypertension subjects as control （ n = 16）. Those arterioles were stained by HE before observation with light microscope for the geometry morphology, including vessel wall thickness （WT）, inner and outer diameter （ID and OD）as well as wall ratio of cross-sectional area to luminal cross-sectional area （WCSA/LCSA）. Results：There was no significant difference regarding the vascular OD among three groups. WT, ratio of WT to ID （WT/ID） and ratio of WCSA/LCSA in hypertension group were significantly higher than those of the controls. And yet, WT, WT/ID and WCSA/LCSA in patients with left ventricular hypertrophy were significantly increased while ID was markedly decreased as compared with hypertension group. Conclusion ： Concentric remodeling occurs in the mesenteric arterioles in patients with essential hypertension, especially those with left ventricular hypertrophy.