Graves'眼病患者治疗前后血清IL-4、IFN-γ和TGF-β检测的临床意义

Clinical Significance of Determination of Changes of Serum IL-4,IFN-γ and TGF-β Levels After Treatment in Patients with Graves' Ophthalmopathy

目的:探讨了G raves'眼病患者治疗前后血清IL-4、IFN-γ和TGF-β水平的变化及意义。方法:应用放射免疫分析和酶联法对33例G raves'眼病患者血清IL-4、IFN-γ和TGF-β的检测,并与35名正常健康人作比较。结果:G raves'眼病患者治疗前血清IL-4、IFN-γ和TGF-β水平均非常显着地高于正常人组(P<0.01)。经治疗1个月后,与正常人组比较仍有显著性差异(P<0.05)。且血清TGF-β水平与IL-4、IFN-γ水平呈正相关(r=0.5728、0.6014,P<0.01)。结论:检测血清IL-4、IFN-γ和TGF-β水平的变化对认识其发病机理和预后观察具有重要的临床价值。

Objective To explore the clinical significance of changes of serum IL-4,IFN-γ and TGF-β levels after treatment in patients with graves＇ ophthalmopathy.Methods Serum TGF-β（with RIA） IL-4,IFN-γ（with ELISA） levels were determined in 33 patients with graves＇ ophthalmopathy and 35 controls.Results Before treatment,Serum IL-4,IFN-γ and TGF-β levels were significantly higher than those in controls（P0.01）.1 month after treatment the levels decreased markedly,but remained apparently different from those in controls（P0.05）.Serum TGF-β and IL-4,IFN-γ levels were mutually positively correlated（r=0.5728,0.6014,P0.01）.Conclusion Determmation of changes of serum IL-4,IFN-γ and TGF-β levels in patient.with Graves＇ ophthalmopathy might be helpful to predicting prognosis and important in the pathogenesis of Graves＇s ophthamopathy.