妊高征肾病患者血清TGF-β_1、IL-8和VEGF检测的临床意义

Clinical Significance of Determination of Changes of Serum TGF-β_1,IL-8 and VEGF Levels in Patients with Pregnancy Induced Hypertension Complicated with Nephropathy

目的:探讨了妊高征肾病患者血清TGF-β1、IL-8和VEGF水平的变化及临床意义。方法:应用放射免疫分析和酶联法对33例妊高征肾病患者进行了血清TGF-β1、IL-8和VEGF测定,并与35名正常健康人作比较。结果:妊高征肾病患者血清TGF-β1、IL-8和VEGF水平均非常显著地高于正常人组(P<0.01),且血清TGF-β1水平与IL-8和VEGF水平呈正相关(r=0.6132、0.5834,P<0.01)。结论:检测妊高征患者血清TGF-β1、IL-8和VEGF水平的变化对患者的病情的判断、临床治疗效果均有重要的临床价值。

Objective To explore the significance of changes of serum TGF-β1,IL-8 and VEGF levels in patients with hypertensive disorder complicating pregnancy.Methods Serum IL-8（with RIA）,serum TGF-β1,VEGF（with ELISA） levels were measured in 33 patients with pregnancy induced hypertension complicated with nephropathy,as well as in 35 healthy controls.Results The serum TGF-β1,IL-8 and VEGF levels in patients were significantly higher than those in controls（P0.01）.Serum TGF-β1 levels were positively correlated to IL-8（r=0.6132,0.5834,P0.01）.Conclusion VEGF levels were closely related with the diseases process of PIH.Determination of their changes might be useful for clinical diagnosis and predicting therapeutic effects in patients with PIH.