脉络宁对COPD患者NPY含量的变化观察

Effect of Maluoning Treatment on Serum Content of NPY in Patients with COPD

目的:探讨脉络宁对慢性阻塞性肺病(chron ic obstructive pu lm onary d isease,COPD)患者血清神经肽(neuro-peptide Y,NPY)含量变化的影响。方法:选择40例应用脉络宁治疗的COPD患者为观察组;另选未用脉络宁治疗的30例COPD患者为对照组。观察组患者在用脉络宁治疗前1d～3d及治疗1年时采血,分别测定血清NPY含量,对照组患者在住院前1d～3d及住院后1年时分别测定血清NPY含量。结果:血清NPY含量,观察组在治疗前为(89.4±15.2)pg/m l,至1年时为(72.9±13.8)pg/m l,对照组在住院前为(90.5±15.6)pg/m l,至1年时为(81.8±14.6)pg/m l,两组治疗前对比无明显差异(P>0.05),1年时相比差异有显著性意义(P<0.05)。结论:脉络宁对COPD患者具有调节血清NPY含量使其减少的作用。

Objective To study the effect of maluoning treatment on serum NPY contents in patients with COPD.Methods To COPD patients were divided into two groups： treatment group（n=40）,control groups（n=30）.Serum NPY contents were determined in two groups patients at 1d～3d before admission and one year later respectively.Results The serum NPY level in two groups of COPD patients were not much different at admission（89.4±15.2）pg/ml vs（90.5±15.6）pg/ml（P0.05）.Serum NPY contents in 40 patients with Maluoning treatment after one year were apparently lower than those in the 30 patients without Maluoning treatment（72.9±13.8）pg/ml vs（81.8±14.6）pg/ml（P0.05）.Conclusion Maluoning could markedly reduce the serum NPY content in patients with COPD.