妊高征患者血浆ET-1和血清INH、D-D检测的临床意义

Clinical Significance of Measurement of Changes of Plasma ET-1 and Serum INH,D-D Levels in Patients with Pregnancy Induced Hypertension

目的:探讨了血浆内皮素-1(ET-1)和血清抑制素(INH)、D-二聚体(D-D)水平在妊高征患者发病中的变化和临床意义。方法:采用放射免疫分析、酶联法和生化法对32例妊高征患者进行了血浆ET-1和血清INH、D-D检测,并与35名正常孕妇作比较。结果:妊高征患者血浆ET-1和血清INH、D-D水平均非常显著地高于正常人组(P<0.01),且血浆ET-1水平与INH、D-D水平呈正相关(r=0.6138、0.5912,P<0.01)。结论:检测妊高征患者血浆ET-1和血清INH、D-D水平的变化对密切监视病情的严重程度、病情的发展均具有重要的临床价值。

Objective To explore the clinical significance of changes of plasma ET-1 and serum INH,D-D levels in patients with pregnancy induced hypertesion（PIH）.Methods Plasma ET-1（with RIA）,serum INH（with ELISA）,D-D（with Biochemistry） were determined in 32 patients with PIH and 35 controls.Results The plasma ET-1 and serum INH,D-D levels were very markedly higher in patients with PIH than those in the controls（P0.01）.Plasma ET-1 levels were positively correlated with serum INH,D-D levels（r=0.6138,0.5912,P0.01）.Conclusion Changes of plasma ET-1 and serum INH,D-D levels to moniter the severity and progress of disease might be of important clinical value in patients with PIH.