对电针反应的大鼠中缝大核神经元的特性

CHARACTERISTICS OF THE NEURONS RESPONDING TO ELECTRO-ACUPUNCTURE IN THE NUCLEUS RAPHE MAGNUS OF THE RAT

在大鼠中缝大核中记录到100个神经元的单位活动,被分类为伤害兴奋型(59个),伤害抑制型(30个),非伤害感受型(5个)和其它类型神经元(6个)。试验了70个神经元对电针的反应,表明电针可激活各类神经元的活动,使大部分伤害兴奋神经元(69.77%)兴奋,伤害抑制神经元(68.42%)抑制。中脑导水管周围灰质有下行纤维投射到中缝大核中,加强对电针反应神经元的活动。全身应用吗啡对电针反应神经元呈现兴奋、抑制和无作用3种型式,但同电针反应型式之间无明显相关关系,表明中缝大核在针刺镇痛与吗啡镇痛中的作用只是部分重合而不是完全一致。

A total of 100 neurons were recorded from the nucleus raphe magnus (NRM), of which 59 were identified as noxious-exaitation neurons; 30 as noxioes-inhibition neurons; 5 as non-noxious neurons; and 6 as non-responsive neurons Seventy neurons were further tested with electro-acupuncture (EA). 69.77% of the noxious-excitation neurons were excited and 68.42% of the noxious -inhibition neurons inhibited by EA. Stimulation of the periaqueductal gray (PAG) could activate the majority of the EA-response neurons. Systemic morphine could also affect the EA-response neurons through the following three patterns: excitation, inhibition and no-effect. No signilicant correlation between the response patterns of EA and morphine was found. The results indicate that the effect of NRM in EA and morphine analgesia is only partially overlapped.