10-羟基喜树碱的制备及机理探讨

Discussion on the Synthesis and Possible Reaction Mechanism of 10 Hydroxycamptothecin

讨论了两步法合成１０－羟基喜树碱，即醋酸介质中喜树碱经过氧化氢氧化成氮氧化物，再经光化重排形成产物。同时对该光化重排反应的机理也作了初步的探讨。

A two step way of preparing the key intermediate 10 hydroxycamptothecin in enantiomerically pure form,which consists of oxidation and photorerrangement,is discussed.The possible mechanism of photorearrangement reaction is also describde.