牙周炎、血脂异常与超敏C-反应蛋白的关系

Relationship among periodontitis,dyslipidemia and high sensitive C-reactive protein

目的通过分析牙周炎患者的血脂指标和超敏C-反应蛋白(hs-CRP)水平,探讨牙周炎、血脂异常和hs-CRP之间的相互关系。方法体检中心体检人群中随机纳入6 190人,年龄在20～89岁。按年龄分组分为:20～40岁组、41～65岁组、≥66岁组;按是否患牙周炎分为:牙周炎组和非牙周炎组;按是否合并血脂异常分为对照组、单纯血脂异常组、单纯牙周炎组和牙周炎+血脂异常组。对所有调查对象均进行总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、脂蛋白a(lpa)和hs-CRP检测。结果与非牙周炎组比较,男性或20～40岁组的牙周炎患者hs-CRP三个水平段(1～3 mg/L、3～10 mg/L和>10 mg/L)的构成比明显升高,而41～65岁组牙周炎患者仅1～3 mg/L和3～10 mg/L两个水平段构成比升高。与单纯血脂异常组比较,单纯牙周炎组TG、LDL-C、lpa和hs-CRP水平明显降低,而牙周炎+血脂异常组TC、TG、LDL-C、LDL-C、lpa和hs-CRP水平明显升高,HDL-C水平则明显降低。结论牙周炎与血循环中hs-CRP水平升高相关,而牙周炎合并血脂异常患者的血脂水平和hs-CRP水平较单纯血脂异常者或牙周炎患者高。因此,在治疗牙周炎的同时,积极预防血脂异常能有效的降低心血管疾病的患病风险。

Objective To analyze the lipid and high sensitive C-reactive protein （hs-CRP） levels in patients with periodontitis and investigate the relationship among periodontitis,dyslipidemia and hs-CRP.Methods 6 190 sample were selected,aged 20 ～ 89 years.Subjects were divided into 3 groups by age： 20 ～ 40,41～ 65,and ≥ 66 years old groups.By whether with periodontal disease,subjects were divided into periodontitis and non-periodontitis groups;by whether with dyslipidemia into control,dyslipidemia,periodontitis,dyslipidemia and periodontitis groups.Total cholesterol（TC）,triglyceride（TG）,high density lipoprotein （HDL-C）,low density lipoprotein（LDL-C）,lipoprotein a（lpa） and hs-CRP were measured.Results Compared to non-periodontitis group,there were three proportions in 20 ～ 40 years old group or male groups at 1～3,3～10 and 10 mg/L hs-CRP was significantly higher（P0.05）.Only proportions at 1～3 mg/L and 3～10 mg/L were higher（P0.05） in 41～ 65 years old group.Compared to the dyslipidemia group,TG,LDL-C,lpa and hs-CRP levels were significantly lower in periodontitis group（P0.05）;TC,TG,LDL-C,lpa and hs-CRP of levels were significantly higher,HDLC level was significantly lower in dyslipidemia and periodontitis groups（P0.05）.Conclusions Periodontitis can induce high level hs-CRP,the lipid level and the hs-CRP level are significantly higher in dyslipidemia and periodontitis.Therefore,dyslipidemia should be prevented to reduce the risk of cardiovascular disease during treating periodontitis.