摘要
目的探讨小剂量左旋多巴治疗对早期帕金森病(PD)患者壳核代谢的影响。方法对20例单侧症状的PD患者(PD组,Hoehn-Yahr 1级)应用小剂量左旋多巴治疗,分别于治疗前后进行壳核的氢质子磁共振波谱(1H-MRS)检测,并与20名正常对照者(正常对照组)比较。结果 PD组治疗前症状对侧壳核N-乙酰天门冬氨酸(NAA)/磷酸肌酸(Cr)比值低于症状侧及正常对照组(均P<0.01),NAA/胆碱(Cho)比值低于正常对照组(P<0.05);PD组治疗后症状对侧壳核NAA/Cr比值显著高于治疗前(P<0.01)。结论小剂量左旋多巴治疗可逆转早期PD患者病损侧壳核神经元的低代谢状态。
Objective To explore the influence of low-dose levodopa therapy on metabolism of putamen in patients with early-stage Parkinson disease (PD). Methods 20 PD patients with unilateral symptoms ( PD group, Hoehn-Yahr stage I ) received low-dose levodopa therapy. The examination of I H-MRS focused on putamens were carried out in the PD group before and after therapy respectively; and the results were compared with 20 normal controls (NC group). Results In PD group before the therapy, the ratio of N-acetyl-l-aspartate (NAA)/ereatine (Cr) in the putamens of symptom's opposite side was significantly lower than those in the symptom's side and NC group ( all P 〈 0. 01 ). The ratio of NAA/Choline (Cho) was significantly lower than NC group ( P 〈 0. 05 ). After therapy, the ratio of NAA/Cr in the putamens of symptom's opposite side was significantly higher than before therapy ( P 〈 0. 01 ). Conclusion The therapy' of low-dose levodopa can reverse the low metabolism of impaired putamens in patients with early-stage PD.
出处
《临床神经病学杂志》
CAS
北大核心
2011年第3期171-173,共3页
Journal of Clinical Neurology
基金
中华国际医学交流基金会默沙东帕金森病科研基金(医基发2008028)
关键词
帕金森病
质子磁共振波谱
壳核
左旋多巴
Parkinson disease
magnetic resonance spectroscopy
putamen
levodopa