摘要
目的检测卵巢癌患者手术及化疗前后HE4和CA125的血清值,探讨卵巢癌患者治疗前后HE4、CA125的变化情况。方法采用酶联免疫吸附试验(ELISA法)检测21例卵巢癌患者治疗过程中血清HE4和CA125水平。数据使用SPSS13.0进行统计学分析。结果卵巢癌患者术后行常规化疗,血清HE4及CA125的水平基本下降到正常。术前HE4中位数水平为796.32pmol/L,第2次后基本恢复正常,为135.61pmol/L;患者术前CA125中位数水平为1280kU/L,第3次化疗后为30.4kU/L,恢复正常。卵巢癌患者治疗过程中HE4与CA125具有较强的相关性,相关系数为0.811。结论 HE4可能作为有助于评判疗效的另一种血清学标志物。
Objective To study the variation of serum HE4 and CA125 levels in patients with ovarian cancer pre-and post-operatively and before and after chemotherapy.Methods HE4 and CA125 levels in pre-and post-operative and chemotherapy serum samples of 21 patients were assayed with enzyme-linked immunosorbent assay.Statistical analyses were performed with SPSS 13.0.Results The levels of HE4 and CA125 of the ovarian carcinoma decreased to normal after operation and chemotherapy.The median value of HE4 was 796.32 pmol/L pre-operative,which decreased to 135.61 pmol/L after the second chemotherapy.While the median value of CA125 was 1 280 kU/L pre-operative,and changed to 30.4 kU/L after the third chemotherapy.The correlation coefficient（r）between HE4 and CA125 was 0.811,which indicates a strong correlation.Conclusion HE4 maybe another serum marker which contributes to the evaluation of curative effect of ovarian cancer.
出处
《中国妇产科临床杂志》
2011年第3期212-215,共4页
Chinese Journal of Clinical Obstetrics and Gynecology
