COX-2和HER-2在食管鳞癌组织中的表达及相关性研究

Expression and clinical significance of COX-2 and HER-2 in esophageal squamous cell carcinoma

目的研究COX-2和HER-2在食管鳞癌(ESCC)组织中的表达及与临床病理特征之间关系。方法采用免疫组织化学方法检测519例食管鳞癌组织中COX-2和HER-2的表达水平,分析两者与临床病理特征之间的关系以及两者之间的相关性。结果 COX-2阳性表达率为411/519(79.2%),COX-2的表达与食管鳞癌分期?分化程度?肿块直径大小,淋巴结转移均无相关性(P>0.05);HER-2阳性表达率为120/519(23.1%),与食管鳞癌分化程度、淋巴结转移数目呈正相关(P<0.05);而与食管癌分期?肿块直径大小无相关性(P>0.05)。HER-2的表达与COX-2的表达之间正相关(r=0.151,P=0.01)。结论 HER-2蛋白与COX-2蛋白在食管鳞状细胞癌中均有不同程度的表达,COX-2可能是食管鳞状细胞癌发生的早期事件;HER-2蛋白过表达可能是食管癌预后不良的一个指标;COX-2在食管鳞状细胞癌中高水平表达且与HER-2密切相关,提示食管鳞状细胞癌中COX-2和HER-2存在相互作用机制并共同促进肿瘤的发生及发展。

Aim To investigate the expression and correlation of cyclooxygenase-2 and HER-2 oncogene in esophageal squamous cell carcinoma.Methods cyclooxygenase-2 protein and HER-2 oncogene expression in 519 cases of esophageal squamous cell carcinoma were detected by immunochemical staining and the relationship between COX-2 and HER-2 was analyzed together with the clinicopathologic characteristics.Results 411 cases of 519（79.2%）esophageal squamous cell carcinoma samples were positive for cyclooxygenase-2.Overexpression of cyclooxygenase-2 was not associated with TNM stage,histological grade,lymph node metastasis and the size of tumor（P0.05）.120 cases of 519（23.1%）esophageal squamous cell carcinoma specimens were positive for HER-2,which correlated with the factors of histologic grade and lymph node metastasis（P0.05）,while not related with TNM stage,the size of tumor.The expression of HER-2 was closely correlated with the expression of COX-2（P0.05）.Conclusion Both COX-2 and HER-2 overexpress in ESCC.COX-2 seems to be an early event in the development of ESCC.HER-2 may play independent prognosis target rule.The expression of COX-2 is significantly related to the expression of HER-2,which indicates that HER-2 and COX-2 can regulate each other and induce the tumorgenesis and development together.