丹参粉针治疗非酒精性脂肪肝的临床观察

Clinical study on non-alcoholic fatty liver treated by Danshen injection

目的观察丹参粉针治疗非酒精性脂肪肝的临床疗效。方法将150例非酒精性脂肪肝患者随机分为治疗组75例,对照组75例,治疗组静脉滴注丹参粉针注射液400 mg,每日一次;对照组静脉滴注硫普罗宁注射液200 mg,每日一次。两组均治疗4周。比较两组病人治疗前后肝脏生化指标:丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、谷氨酰转肽酶(GGT)、总胆红素(Tb il),血脂指标:总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C),以及CT测量的肝/脾值。结果丹参粉针治疗组能显著改善非酒精性脂肪肝患者的各项指标,与治疗前比较有统计学意义(P<0.05);治疗组总有效率(89.4%)明显高于对照组(70.6%),两组比较有统计学意义(P<0.05)。结论丹参粉针对非酒精性脂肪肝有明显的治疗作用。

Aim To study the efficacy of Danshen injection in the treatment of non-alcoholic fatty liver.Methods 150 patients with non-alcoholic fatty liver were randomly divided into treatment group（75 cases）and control group（75 cases）.The treatment group was given the Danshen injection（400 mg）,once a day,while control patients received Tiopronin injection（200 mg）via intravenous drop,once a day.Four weeks later,alanine aminotransferase（ALT）,aspartate aminotransferase（AST）,gamma-glutamyl transpeptidase（GGT）,total bilirubin（Tbil）,total cholesterol（TC）,triglyceride（TG）,low density lipoprotein cholesterol（LDL-C）,high density lipoprotein cholesterol（HDL-C）,the ratio value of liver to spleen by CT determination were compared between the two groups.Results The indexs of non-alcoholic fatty liver disease patients could be improved in the treatment group,which had statistical significance contrasted with the patients before treatment.Tests indicated statistically significant difference in the readings and effective rate between the two groups（P0.05）.Conclusion Danshen injection is effective in the treatment of non-alcoholic fatty liver.