我院313例地高辛血药浓度监测结果分析

Concentration analysis of Serum Digoxin of 313 Patients

目的 分析该院313例地高辛血药浓度监测结果,为临床合理用药提供参考.方法 采用微粒酶免疫检验技术（MEIA）测定患者的地高辛血药浓度,并对所监测的结果进行统计学分析.结果 在监测的313例次地高辛血药浓度病例中,血药浓度在0.5～2.0 μg·L-1的有222例（70.9%）;＜0.5 μg·L-1的有52例（16.6%）;＞2.0 μg·L-1的有39例（12.5%）.地高辛血药浓度受患者年龄、性别等因素影响.结论 血药浓度监测与临床紧密结合,对确保地高辛临床疗效,减少毒性反应的发生,具有重要意义.

Aim To analyze the result of the serum digoxin concentration Yijishan Hospital of Wannan Medical College,in order to offer reference about clinical safety and rational use.Methods The serum digoxin concentrations were determined by the microparticle enzyme immunoassay（MEIA）,and the monitoring results were subjected to statistical analysis.Results Of the total 313 cases treated with digoxin,the serum digoxin concentration ration in 39（12.5 %）was above 2.0 μg·L-1,and it was 0.5～2.0 μg·L-1 in 222（70.9 %）and less than 0.5 μg·L-1 in 52（16.6 %）.The serum digoxin concentrations were affected by age and gender.Conclusions To ensure clinical efficacy and reduce incidence of toxic reactions,it is of great importance to monitor the serum digoxin concentration and formulate individual dosage regimen.