Clif基因多态性与高脂血症的关联分析

Analysis of Clif gene polymorphism on hyperlipidemia

目的:探讨Clif基因多态性与高脂血症的关系,为高脂血症的预防及治疗提供新的依据。方法:采用病例-对照研究设计,收集205例高脂血症病例组和281例正常对照组的血液标本和临床资料。通过特异序列聚合酶链反应(SSP-PCR),检测Clifrs2289709,rs62758860的基因多态性与高脂血症的相关性。结果:病例组与对照组比较Clifrs2289709,rs62758860无显著差异(P>0.05)。针对高脂血症进行分型,结果显示Clifrs2289709高脂血症IIb型病例组与对照组相比较,有显著差异性(P<0.05)。结论:Clif基因多态性与高脂血症IIb型存在相关性。

Objective： To study the relationship of Clif gene polymorphism and hyperlipidemia to provide a new basis for the prevention and treatment of hyperlipidemia.Methods： A case-control study： to collect 205 patients with hyperlipidemia（case group） and 281 normal volunteers（control group）,and to collect blood samples and clinical data.Specific sequences by polymerase chain reaction（SSP-PCR） was used to detect Single nucleotide polymorphism（SNP） of Clif gene（rs2289709,rs62758860）.Results： The Clif rs2289709,rs62758860 of case group and control group were no significant difference（P0.05）.But there were significant difference between type IIb hyperlipidemic sub-group and control group on Clif rs2289709（Palleo-IIb=4.738×10-4,or alleo-IIb=2.959）.Conclusion： Clif gene polymorphism was associated with type IIb hyperlipidemia.