性别差异与中国人群肠易激综合征发病相关性的Meta分析

Meta-analysis of association of gender and attack rate of irritable bowel syndrome in Chinese people

目的分析性别差异与中国人群肠易激综合征(IBS)发病相关性,探讨性激素在IBS发病中的可能作用,为IBS的干预提供理论基础。方法检索1999年至2010年中国生物医学文献数据库、中国科技期刊全文数据库、中国知网收录的中国国内有关性别差异与IBS发病相关性研究的论文,应用Meta分析方法对有关性别差异与IBS发病相关性的病例对照研究结果进行定量综合分析,Review manager4.2进行一致性检验及合并OR值和95%可信区间的计算。结果共检索到28篇文献,其中符合入选标准的文献5篇,包括IBS患者1334例,对照组9064例。一致性检验χ2=3.84,P>0.10,表明纳入的5篇文献具有同质性。合并OR值为0.79,OR<1,且95%可信区间为0.70～0.89;Z=3.91,P<0.0001。表明中国人群IBS患病存在性别差异(女性患病率高于男性)。纳入Meta分析的各文献性别差异漏斗图基本对称,提示Meta分析结果发表偏倚较小。结论中国人IBS患病存在性别差异,女性患病率高于男性。

Objective To synthetically evaluate the association of gender and attack rate of irritable bowel syndrome（IBS） in Chinese people and investigate the potential role of sexual hormone on IBS invasion for proving rational basis of IBS therapy.Methods Chinese biomedical literature database,Chinese journal full-text database and China knowledge resource integrated database were searched for collecting the literatures about the association of gender and attack rate of IBS in Chinese people published from 1999 to 2010.Meta-analysis was used to synthetically and quantitatively evaluate the case-control studies.Review Manager 4.2 was utilized to do homogeneity checking and calculate odds ratio（OR） and 95%confidence interval（95%CI）.Results A total of 28 literatures were searched,and 5 studies met the inclusion criteria were identified for meta-analysis.In all of 5 studies,1 334 patients and 9 064 controls were involved.χ2 test for homogeneity of 5 studies（χ2 =3.84,P〉0.10） suggested there was significant homogeneity in these studies.The results of combined statistics test showed there was significant difference ingender of IBS attack rate.The attack rate of female was higher than that of male（pooled OR values=0.79,95%CI：0.70-0.89,Z=3.91,P〈0.0001）.The shapes of the funnel plots seemed symmetrical suggested that there was no obvious publication bias.Conclusions There is significant difference in attack rate of IRS in Chinese people with different gender,and female is more susceptible to IBS.