慢性阻塞性肺疾病稳定期患者饮食干预研究

Dietary intervention studies in stable COPD patients

目的本研究是为了评估在合并营养不良的慢性阻塞性肺疾病患者中,进行饮食干预所带来的影响,从而指导临床医师工作。方法针对88例慢性阻塞性肺疾病稳定期合并营养不良的患者进行了随机非双盲实验。研究组受到了饮食方面的忠告和饮食强化指导,而对照组仅接收到了饮食忠告传单。在饮食干预前后分别测定他们的营养状况、肺功能等调查。结果研究组比对照组每天摄入了更多的热量和蛋白质。研究组在饮食干预期后体重及其他营养指标、呼吸功能中的FVC和间接反映骨骼肌质量改善的优势手握力较对照组增加并且差异有统计学意义。结论在实验期间,个体化饮食干预可给慢性阻塞性肺疾病稳定期合并营养不良的患者带来益处,使他们的体重增加、营养状态改善,肺功能和骨骼肌强度有一定提高,最终使生命质量得到改善。

Objective A study was undertaken to assess the impact of dietary counseling and food fortification on outcome in patients with COPD who were at risk of malnutrition,and giving clinical provide conducting.Methods A randomized controlled unblined trial was performed in 88 patients with COPD who were malnutrition.The intervention group received dietary counselling and advice on food fortification and the controls received a dietary counselling leaflet.Outcome measures were nutritional status,skeletal muscle strength,respiratory function.Results The study group intaked more energy and protein than controls.The study group gained weight after the intervention period than the control group.At same times,study group＇s body composition、FVC which is one of respiratory function and the handgrip strength which can reflect skeletal muscle strength were all increased,but controls＇were declined,there was significant difference.Conclusion Dietary intervention include dietary counseling and food fortification resulted in weight gain and improvements in outcome in nutritionally at-risk patients which COPD,and improvements in quality of life,during the intervention period.