血清CA125水平对卵巢癌诊断价值的Meta分析

Diagnostic value of serum CA125 level on ovarian tumor:a meta-analysis

目的系统评价血清CA125水平对卵巢癌的诊断价值及临床应用前景。方法计算机检索Cochrane图书馆、Medline及CBMDisc数据库,检索年限均从建库到2010年12月,收集有关血清CA125诊断卵巢癌的诊断试验,手工检索相关杂志、会议论文集、学位论文汇编等。根据Cochrane系统评价方法筛选研究并提取数据,采用Meta-Disc1.4版软件进行Meta分析。结果 27篇文献符合纳入标准入组本系统评价,其中卵巢癌病例组1,456例,正常或良性对照组3,014例。Meta分析的结果显示:血清CA125的诊断优势比DOR为45.88(95CI=27.25～77.27),敏感度和特异度分别为84.1(95CI=82.2～86.0)和82.2(95CI=80.8～83.6),阳性似然比和阴性似然比分别为6.98(95CI=4.75～10.26)和0.18(95CI=0.12～0.26)。结论现有证据表明,血清CA125诊断卵巢癌的敏感度和特异度较高,可作为临床辅助诊断卵巢癌的有效工具。

Objective To evaluate the diagnostic value of serum CA125 level on ovarian cancer.Methods Based on the principles and methods of Cochrane systematic reviews,we searched the Cochrane library,Medline and CBMdisc databases from inception to December 2010.Articles related to the diagnostic value of serum CA125 on ovarian cancer were selected.Related journals were also searched manually.Data analysis was conducted by Meta-Disc1.4 software.Results Twenty-seven studies with a total of 1456 ovarian cancer cases and 3014 controls were included.The results of meta-analysis showed that：the diagnostic odds ratio of serum CA125 level on ovarian cancer was 45.88（95 CI =27.25 ～ 77.27）,sensitivity and specificity were 84.1（95 CI = 82.2 ～ 86.0） and 82.2（95 CI =80.8 ～83.6） respectively,positive likelihood ratio and negative likelihood ratio were 6.98（95 CI =4.75 ～10.26） and 0.18（95 CI = 0.12 ～ 0.26） respectively.Conclusion Available evidence suggests that serum CA125 have higher sensitivity and specificity on diagnosis of ovarian cancer,it can be used as an effective tool for diagnosis of ovarian cancer.