他卡西醇软膏联合地奈德乳膏治疗寻常型斑块状银屑病的疗效观察

Efficacy of tacalcitol ointment combined with desonide cream in the treatment of plaque vulgaris psoriasis

目的探讨他卡西醇软膏联合地奈德乳膏治疗寻常型斑块状银屑病的疗效。方法将66例寻常型斑块状银屑病患者按随机数字表法分为联合治疗组（33例）以及地奈德组（33例）。联合治疗组早上用地奈德乳膏涂抹1次，晚上外用他卡西醇软膏1次；地奈德组单用地奈德乳膏，2次，d，疗程均为8周。结果联合治疗组的有效率为78．79％（26／33），低于地奈德组的84．85％（28／33），但差异无统计学意义（P〉0．05）。地奈德组复发率为25．00％（7／28），联合治疗组为11．54％（3／26），两组比较差异无统计学意义（P〉0．05）。观察期间均未发生严重不良反应。结论他卡西醇软膏联合地奈德乳膏治疗寻常型斑块状银屑病疗效与单用地奈德乳膏相当，但两者联合应用可减少糖皮质激素的用量，减轻药物的局部不良反应，且使用安全。

Objective To evaluate the efficacy of tacalcitol ointment combined with desonide cream in the treatment of plaque vulgaris psoriasis. Methods Sixty-six patients with plaque vulgarls psoriasis were assigned into combination treatment group and desonide sole treatment group by random digits table with 33 cases each. In combination treatment group, desonide cream was applied 1 time per day in the morning and tacalcitol ointment was applied 1 time per day at night. In desonidc sole treatment group, desonide cream was applied twice one day. The therapy for two groups continued for 8 weeks. Results The total effective rate in combination treatment group was 78.79%（ 26/33 ）, and it was lower than that in desonide sole treatment group [ 84.85% （28/33）], but there was no significant difference between two groups （P 〉 0.05 ）. The recurrence rate was 25.00% （7/28） in desonide sole treatment group and 11.54% （3/26） in combination treatment group,there was no statistical difference between Lwo groups （P 〉 0.05 ）. There was no serious side effect during observation. Conclusions Tacalcitol ointment combined with desonide cream has no more effective for plaque vulgaris psoriasis than that of desonide cream alone. The combined use of these two drugs could reduce the dosage of steroid and side effect.