肝动脉介入性热灌注化疗栓塞治疗不能手术切除的原发性肝癌近期疗效分析

Early stage therapeutic effect analysis of thermochemotherapy and embolization via hepatic artery intervention in the treatment of unresectable primary liver cancer

目的探讨肝动脉介入性热灌注化疗栓塞治疗不能手术切除的原发性肝癌的近期疗效。方法 39例不能手术切除的原发性肝癌患者,经股动脉选择性肝动脉置管,采用表阿霉素(EADM)、5-氟尿嘧啶(5-FU)、丝裂霉素(MMC)、顺铂(CDDP)行热灌注化疗栓塞治疗,间隔40～50 d再次治疗,2次治疗后评价近期治疗效果及不良反应。结果 39例患者显效8例(20.5%),有效14例(35.9%),稳定15例(38.5%),进展2例(5.1%),总有效率为56.4%。AFP下降>50%者16例,其中11例恢复正常。结论肝动脉介入热灌注化疗栓塞治疗原发性肝癌安全有效,其远期疗效有待进一步观察。

Objective To explore early stage therapeutic effect of thermochemotherapy and embolization via hepatic artery intervention in the treatment of unresectable primary liver cancer.Methods For 39 cases of unresectable primary liver cancer patients,a catheter was set in the selective hepatic artery via femoral artery.Epirubicin（EADM）,5-fluracil（5-FU）,mitomycin（MMC） and cis-platinum（CDDP） were used for thermochemotherapy and embolization treatment.The process was repeated once 40 to 50 days later.After the two treatment periods ended,the early effects and side-effects were observed.Results Of 39 cases,8 cases received excellent effect（20.5%）,14 cases good effect（35.9%）,15 cases stabilization（38.5%）,and 2 cases advancement,with a total effective rate of 56.4%.AFP dropped over 50% in 16 cases,among which 11cases returned to normal.Conclusions The treatment of primary liver cancer by means of thermochemotherapy and embolization via hepatic artery intervention is effective and safe,but the long-term effects need further observation.