摘要
Tumor angiogenesis plays an important role in the growth, invasion and metastasis of breast cancer, therefore re-cently a very active area of breast cancer research involves the addition of antiangiogenic therapy. Numerous clinical studies for several antiangiogenic agents have recently been conducted in breast cancer patients and have shown clinically significant improvement in outcomes. This review gives a brief background to breast cancer angiogenesis, also focusing on current prog-ress in the field of antiangiogenic therapy for breast cancer and issues regarding future therapeutic development.
Tumor angiogenesis plays an important role in the growth, invasion and metastasis of breast cancer, therefore re-cently a very active area of breast cancer research involves the addition of antiangiogenic therapy. Numerous clinical studies for several antiangiogenic agents have recently been conducted in breast cancer patients and have shown clinically significant improvement in outcomes. This review gives a brief background to breast cancer angiogenesis, also focusing on current prog-ress in the field of antiangiogenic therapy for breast cancer and issues regarding future therapeutic development.
关键词
抗血管生成
乳腺癌
治疗
肿瘤血管生成
RESS
临床
breast cancer
angiogenesis
antiangiogenic therapy
vascular endothelial growth factor （VEGF）
bevacizumab
