初治鼻咽癌IMRT和常规放疗的急性不良反应的临床分析

A comparative observation of acute adverse reaction of IMRT and conventional radiotherapy for nasopharyngeal carcinoma

目的观察初治鼻咽癌调强放疗和常规放疗的急性不良反应,比较两组的差异。方法将60例初治鼻咽癌患者分为常规放疗组(33例)和调强放疗组(27例),观察放疗中患者的急性皮肤反应,口干,口咽黏膜炎,急性腮腺肿胀等急性不良反应。结果调强放疗组患者的急性皮肤反应,口干和急性腮腺水肿等急性不良反应明显低于常规放疗组,对口腔黏膜炎调强放疗并无优势。结论采用调强放射治疗可以减轻患者的皮肤反应,口干,急性腮腺水肿等早期不良反应。

Objective To compare the acute adverse reaction of radiotherapy for newly diagnosed nasopharyngeal carcinoma using conventional or intensity modulated radiation therapy（IMRT）.Methods Sixty newly diagnosed nasopharyngeal carcinoma patients were randomized to 2 groups：conventional radiotherapy group（n=33）and IMRT group（n=27）.Acute toxic reactions including acute skin reaction,xerostomia,oral mucositis and acute parotid edema were observed.Results The incidences of acute skin reaction,xerostomia and acute parotid edema in IMRT group were significantly lower than those in the conventional radiotherapy group,the incidence of oral mucositis was similar in the 2 groups.Conclusion IMRT can significantly reduce the incidences of acute skin reaction,xerostomia and acute parotid edema compared with conventional radiotherapy in nasopharyngeal carcinoma.