内镜下氩离子凝固术联合雷贝拉唑治疗Barrett食管的疗效分析

Clinical analysis of argon plasma coagulation combined with Rabeprazole for Barrett's esophagus

目的探讨内镜下氩离子凝固术联合雷贝拉唑治疗Barrett食管疗效。方法选择经电子胃镜检查及病理组织学检查确诊为Barrett食管患者181例,随机分成3组,A组(56例)为单纯雷贝拉唑治疗组;B组(60例)为单纯内镜下氩离子凝固术治疗组;C组(65例)为内镜下氩离子凝固术联合雷贝拉唑治疗组。所有入选患者在首次治疗的3、6、12个月内随访复查内镜及病理组织学检查。结果 A、B、C三组在首次治疗的3、6、12个月内随访,A组总有效率分别为5.4%、4.9%、3.1%;B组总有效率分别为85.0%、82.4%、85.4%;C组总有效率分别为90.8%、92.5%、91.5%。以上两两组间比较均有统计学意义(P<0.05)。结论内镜下氩离子凝固术联合雷贝拉唑治疗Barrett食管是安全有效的,值得临床推广与应用。

Objective To study the effects of argon plasma coagulation combined with Rabeprazole on Barrett＇s esophagus.MethodsTotally 181 patients with Barrett＇s esophagus diagnosed by endoscope and pathological method were randomized into three groups：group A（n=56） were treated with Rabeprazole;group B（n=60） were treated with argon plasma coagulation and group C（n=65） were treated with argon plasma coagulation combined with Rabeprazole.All the patients were rechecked by endoscope and pathological method within 3,6 and 12 months after treatment.Results The follow-up went within 3,6 and 12 month after the first treatment.The total effective rates in group A were 5.4%,4.9%,3.1% respectively;those of group B were 85.0%,82.4%,85.4% respectively and those of group C were 90.8%,92.5%,91.5% respectively.There were statistical differences between groups（P0.05）.Conclusion Argon plasma coagulation combined with Rabeprazole in the treatment of Barrett＇s esophagus is effective and safe and is worth applying and extending in clinics.