摘要
目的:了解本院新生儿科10年来金黄色葡萄球菌败血症的临床特点及耐药性变迁,为早期诊断及指导临床用药提供依据。方法:对2001年1月至2006年1月收治的新生儿金黄色葡萄球菌败血症(第1组)的临床资料及药物敏感情况进行回顾性分析。并与2006年2月至2011年1月收治的金黄色葡萄球菌败血症(第2组)的调查结果进行比较。结果:10年来金黄色葡萄球菌败血症95例,第一组52例,第二组43例。新生儿金黄色葡萄球菌败血症早期症状不典型,以发热、皮肤粘膜化脓性感染、黄疸多见,77%病例C反应蛋白升高。近5年来,院内感染引起金黄色葡萄球菌败血症明显增多,耐药性明显增高。对青霉素、苯唑青霉素及红霉素有很高的耐药率。多重耐药明显,对常用的头孢菌素近年有明显增高趋势。对阿米卡星、环丙沙星耐药率低,对万古霉素100%敏感。结论:新生儿金黄色葡萄球菌败血症临床表现缺乏特异性。近年来院内感染有增高趋势,对青霉素等常用抗生素普遍耐药,头孢类抗生素耐药性上升明显。控制院内感染,对可疑患儿尽快做血培养及药敏试验,根据药敏试验合理应用抗生素,是防治新生儿金黄色葡萄球菌败血症的关键。
Objective： To explore the evidence of clnical drug using of antibiotics for the treatment of infant septicemia resulted from slaphylococcus aureus. We studied the clinical features and drug tolerance tendency of the disease in recent 10 years. Method： We reviewed data of the cases （ in Group Ⅰ ） of septicemia from Jan. 2001 to Jan. 2006. And then compared with the cases （ Group Ⅱ） from Feb. 2006 to Jan. 2011. Result： In recent 10 years, 95 cases infomt septicemia （52 cases in group Ⅰ, 43 cases in group Ⅱ） resulted from staphylococcus aureus, Most of them with atypical symptoms, such as fever, mucocutaneous pyogenic infection and icterus. There＇s 77% of all with the increase of CRP. In recent 5 years, as the more cases of infant septicemia in hospital, They were 100% sensitivity to vancomycin, There＇s high tolerance to penicillins, oxacillin sodium and erythromycin. For the multiple durg tolerance. There＇s strong tendency of tolerance to cephalosporin with less tolerance to amikacin and ciprofloxacin. Conclusion： It is deficients with specicty of clinical symptoms for infant septicemia resulted from staphylococcus aureus. There＇s more and more durg tolerance, esp to the general antibiotics such as penicillins even cephalosporin. It＇s the key to treat the disease with controlling hospital infection, select properly antibiotics according to the durg sensitive test and culturing of blood sample fastly for the suspected patients.
出处
《河北医学》
CAS
2011年第7期891-893,共3页
Hebei Medicine
