期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

慢性鼻窦炎嗅觉障碍嗅上皮中IGF-1R和Ki-67的表达及意义 被引量：1

IGF-1R and Ki-67 expressions in olfactory epithelium of patients suffering from dysosmia caused by chronic sinusitis
原文传递
导出
摘要 目的探讨慢性鼻-鼻窦炎嗅觉功能障碍的发病机制和胰岛素样生长因子-1R(insulin-like growth factor 1R,IGF-1R)和Ki-67在嗅黏膜中表达的意义。方法取32例慢性鼻-鼻窦炎患者作为失嗅组,11例单纯鼻中隔偏曲行鼻中隔矫正术者作为对照组,应用免疫组织化学技术检测IGF-1R和Ki-67在两组嗅黏膜表达的分布。结果与对照组相比,实验组嗅黏膜Ki-67和IGF-1R表达明显减少(P<0.05)。结论慢性鼻-鼻窦炎嗅黏膜的再生能力明显减弱,与IGF-1R减少有关。 Objective To study the pathogenesis of dysosphresia in patients with chronic sinusitis,and to discuss expressions and significance of IGF-1R and Ki-67 in olfactory mucosa.Methods There were 32 cases of chronic sinusitis in the experimental group,and 11 cases in the control group.IGF-1R and Ki-67 expressions were determined by immunohistochemistry.Tissue sections were observed under an optical microscope.Results Expressions of IGF-1R and Ki-67 in the olfactory epithelium of 32 patients suffering from the dysosmia were lighter than those in the control group（P0.05）.Conclusion IGF-1R promoting regeneration in the olfactory epithelium was notably decreased in the ofactory epithelium of chronic sinusitis patient and may lead to ofactory dysfunction.
作者 刘庆华 李志春
机构地区 厦门大学附属第一医院耳鼻咽喉-头颈外科 福建医科大学附属第一医院耳鼻咽喉-头颈外科
出处 《山东大学耳鼻喉眼学报》 CAS 2011年第3期55-57,61,共4页 Journal of Otolaryngology and Ophthalmology of Shandong University
关键词 胰岛素样生长因子-1R KI-67 鼻窦炎 嗅上皮 嗅觉障碍 Insulin-like growth factor 1 R Ki-67 Sinusitis Olfactory epithelium Dysosmia
分类号 R765.63 [医药卫生—耳鼻咽喉科]
  • 相关文献

参考文献9

  • 1楚士东,李志春,舒畅,张晖萍,易自翔.慢性鼻窦炎鼻息肉失嗅症患者嗅上皮细胞凋亡及相关基因BCL-2,BAX的表达[J].山东大学基础医学院学报,2004,18(6):337-339. 被引量：4
  • 2Miwa T, Moriizumi T, Horikawa I, et al. Role of nerve growth factor in the olfactory system[J]. Micro Res Tech, 2002, 58 ( 3 ) : 197-203.
  • 3孙安纳,柳端今.五味试嗅液的研制及健康青年人嗅阈测试[J].中华耳鼻咽喉科杂志,1992,27(1):35-38. 被引量：24
  • 4Suzuki Y, Takeda M. Expression of insulin-like growth factor family in the rat olfactory epithelium [J].Anat Embryol ( Berl), 2002, 205 (5-6) .401-405.
  • 5McCurdy R D, Feron F, McGrath J J, et al. Regulation of adult olfactory neurogenesis by insulin-like growth factor-I[J]. Eur J Neurosci, 2005,22(7) :1581-1588.
  • 6Pixley S K, Dangoria N S, Odoms K K, et al. Effects of insulin-like growth factor 1 on olfactory neurogenesis in vivo and in vitro[J]. Ann N Y Acad Sci, 1998, 30 ( 855 ) :244-247.
  • 7Cattoretti G, Becker M H, Key G, et al. Monoclonal antibodies against recombinant parts of the Ki-67 antigen (MIB 1 and MIB 3 ) detect proliferating cells in micro- wave-processed formalin-fixed paraffin sections [J].J Pathol, 1992,168 (4) :357-363.
  • 8Koohdani F, Sasani F, Mohammad K , et al. Comparison of Ki-67 antigen expression and K-ras mutation in lung tumours induced by urethane in mice [J]. J Sing Med, 2009,50(7 ) :729-733.
  • 9刘庆华,李志春.嗅感觉神经元的再生调控及与嗅觉障碍的关系[J].山东大学耳鼻喉眼学报,2006,20(2):179-182. 被引量：3

二级参考文献28

  • 1楚士东,李志春,舒畅,张晖萍,易自翔.慢性鼻窦炎鼻息肉失嗅症患者嗅上皮细胞凋亡及相关基因BCL-2,BAX的表达[J].山东大学基础医学院学报,2004,18(6):337-339. 被引量：4
  • 2柳端今，国外医学耳鼻咽喉科学分册，1990年，14卷，285页
  • 3Lee S H,Im HH,et al.Olfactory mucosal findings in the patients with persistent anosmia after endoscopic sinus surgery[J].Ann Otol Phinol Laryngol,2000,109,720-725.
  • 4Hong SC,Leopold DA,Oliverio PJ,et al.Relation between CT scan findings and human sense of smell[J].Otolargol Head Neck Surg,1998,118:183-186.
  • 5Haunstetter A,Izumo S.A poptosis:basic mechanisms and implications for cardiovascular disease[J].Circ Res,1998,82 (11),11-29.
  • 6Voyron S,Giacobini P,Tarozzo G,et al.Apoptosis in the development of the mouse olfactory epithelium[J].Brain Res Dev Brain Res,1999,115(1):49-55.
  • 7Carr VM,Farbman AI.The dynamics of cell death in the olfactory epithelium[J].Exp Neurol,1993,124(2):308-314.
  • 8Ge Y,Tsukatani T,Nishimura T.Cell death of olfactory receptor neurons in a rat with nasosinusitis infected artificially with staphylococcus[J].Chem Senses,2002,27 (6):521-527.
  • 9Graziadei PP.Continuous nerve renewal in the olfactory system.In:Handbook of Sensory Physiology[M].Vol 9.Berlin:Springer,1978.55-58.
  • 10Murray RC,Calof AL.Neuronal regeneration:lessons from the olfactory system[J].Semin Cell Dev Biol,1999,10(4):421-431.

共引文献27

同被引文献10

  • 1Holbrook Eric H,Leopold Donald A.An updated review of clinical olfaction. Current opinion in otolaryngology & head and neck surgery . 2006
  • 2Kivity Shaye,Ortega-Hernandez Oscar D,Shoenfeld Yehuda.Olfaction--a window to the mind. The Israel Medical Association journal : IMAJ . 2009
  • 3Erina Kuranaga.Caspase signaling in animal development. Development Growth & Differentiation . 2011
  • 4Sebastien Brot,Veronique Rogemond,Valerie Perrot.CRMP5 Interacts with Tubulin to Inhibit Neurite Outgrowth, Thereby Modulating the Function of CRMP2. Journal de Neuroradiologie . 2010
  • 5Martin M. Müller,Johannes Middelanis,Carola Meier,Daniel Surbek,Richard Berger.17β-Estradiol Protects 7-Day Old Rats From Acute Brain Injury and Reduces the Number of Apoptotic Cells. ORIGINAL ARTICLES . 2013
  • 6Miwa Takaki,Moriizumi Tetsuji,Horikawa Isao,Uramoto Naoki,Ishimaru Tadashi,Nishimura Toshiro,Furukawa Mitsuru.Role of nerve growth factor in the olfactory system. Microscopy Research and Technique . 2002
  • 7Kern R C.Chronic sinusitis and anosmia: pathologic changes in the olfactory mucosa. Laryngoscope . 2000
  • 8Nuri Yun,Chiho Kim,Hyeseon Cha,Woo Jin Park,Hirohiko Shibayama,Il-Seon Park,Young J. Oh.??Caspase-3-mediated cleavage of PICOT in apoptosis(J)Biochemical and Biophysical Research Communications . 2013
  • 9Experimental Sinusitis in a Rhinogenic Model(J)The Laryngoscope . 2009 (2)
  • 10Pothana Saikumar,Zheng Dong,Valery Mikhailov,Michael Denton,Joel M Weinberg,Manjeri A Venkatachalam.??Apoptosis: definition, mechanisms, and relevance to disease(J)The American Journal of Medicine . 1999 (5)

引证文献1

山东大学耳鼻喉眼学报
2011年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部