羧酸制备伯胺的方法综述

Review of the Preparation of Primary Amine from Carboxylic Acid

系统综述了羧酸制备伯胺的各种常用方法,包括羧酸通过酰胺化制备伯胺和羧酸还原为醇、酮或醛后再经氨解反应得到伯胺,以及羧酸直接转化为伯胺的方法,并指出了各种方法的优点以及存在的问题。最后,对羧酸制备伯胺的方法进行了展望。

In this paper,various common methods to preparing primary amine from carboxylic acid were systematically summarized.They included primary amine prepared through amidation of carboxylic acid,carboxylic acid firstly reduced to alcohol,ketone and aldehydes and followed by ammonolysis for preparing primary amine,and direct conversion of carboxylic acid.Meanwhile,the advantages and problems existing in each method were pointed out.Finally,the preparation of primary amine from carboxylic acid were prospected.